The top 10 include: Cholesterol metabolism, Lipid and atherosclerosis, HIF-1 signaling pathway, Malaria, Chagas disease, AGE-RAGE signaling pathway in diabetic complications, Insulin resistance, Rheumatoid arthritis, Adipocytokine signaling pathway, and AMPK signaling pathway. The gene discussed is HIF1A; the disease is rheumatoid arthritis.