In support of biochemical findings, our histopathological examination revealed severe interstitial nephritis consisting of mononuclear cell infiltration and tubular degeneration in the kidney tissue of rats after DOX administration, which is consistent with the literature data (Owumi et al., 2021; AlAsmari et al., 2022) It is noteworthy that MYC pre-treatment significantly reduced the elevation of creatinine and BUN resulting from DOX administration and improved histological interstitial nephritis and tubular degeneration. This evidence concerns the gene MYC and interstitial nephritis.