Wang et al.19 investigated the effects of Cu-DDC on PCA and identified five key cell death-related genes associated with its mechanism of action.19 Their study revealed that genes like CDKN2A, PRC1, and CDK1 are over-expressed in PCA and correlate with disease-free survival, suggesting that Cu-DDC may enhance therapeutic outcomes by targeting these pathways. The gene discussed is CDKN2A; the disease is posterior cortical atrophy.