XDH and hemophagocytic syndrome: HLH has also been reported in association with several other drugs beyond trimethoprim/sulfamethoxazole, including non-antibiotics such as lamotrigine (an antiepileptic agent) and allopurinol (a xanthine oxidase inhibitor).32 Rare case reports have also implicated combinations of drugs such as haloperidol and quetiapine, sometimes involving substances like cocaine.