PSMA2 and Miosis: Brimonidine known to induces miosis primarily through its alpha-2 adrenergic effects.[5,7] Unlike brimonidine, aproclonidine does not induce miosis.[18] Although both drugs are alpha-2 adrenergic agonists, the higher selectivity of brimonidine for alpha-2 receptors and the minimal alpha-1 adrenergic effects account for their distinct impact.