TGFB1 and Hepatic fibrosis: (1) Metabolites inhibiting fibrosis by activating the PI3K/AKT signaling pathway: quercetin reduces liver injury by inhibiting TGF-β1/SMADs signaling and inhibiting autophagy in BDL-or CCl by activating PI3K/AKT signaling 4-inducing hepatic fibrosis.