AKT1 and liver dysplastic nodule: These findings suggest that mangiferin can reduce the TGF-β1-mediated elevation of Col I, FN, and α-SMA through the PTEN/PI3K/AKT pathway, thereby reducing inflammation and oxidative stress in DN, thereby inhibiting RIF.[110] Resveratrol inhibits the myofibroblast phenotype and fibrosis formation in UUO kidneys by targeting fibroblast-myofibroblast-myofibroblast differentiation (FMD) and EMT.