It has a cardioprotective effect on ISO-induced myocardial fibrosis.[55] Allicin pretreatment can prevent myocardial ischemia-reperfusion injury and activate the miR-19a-3p/PI3K/AKT pathway, thereby reducing myocardial fibrosis.[56] Astragalus membranaceus (Cal), the main active ingredient of Astragalus membranaceus, has been reported to have therapeutic effects on cardiac dysfunction after myocardial infarction. This evidence concerns the gene AKT1 and myocardial infarction.