TGFB3 and Hepatic fibrosis: Thymoquinone (TQ), the main active metabolite extracted from medicinal blackgrass, partially alleviates hepatic fibrosis by blocking TLR4 expression and PI3K/AKT phosphorylation on activated HSCs.[74] Hovenianin A alleviates hepatic fibrosis by inhibiting the PI3K/AKT pathway induced by TGF-β3 in HSCs.[75] Gynostemma pentaphylla inhibits the PI3K/AKT pathway to treat hepatic fibrosis.[76] Tanshinol is a water-soluble bioactive monomer purified from the dried root of Salvia miltiorrhiza and has been reported to exert hepatoprotective efficacy in rodents.