Therefore, DMix has a protective effect on the kidney of DN rats, which may be related to the inhibition of PI3K/AKT/mTOR signaling pathway and activation of renal autophagy by this traditional drug.[164] Taohe Chengqi decoction may inhibit inflammatory process, reduce ECM deposition and reverse EMT through PI3K/AKT/mTOR and HIF-1α/VEGF signaling pathways, thereby exerting its effect on RF.[165] Zhenwu decoction treatment reduced the expression levels of TGF-β and Wnt, and increased the expression levels of Nrf2, PI3K and AKT in renal tissues. The gene discussed is TGFB1; the disease is liver dysplastic nodule.