AKT1 and Hepatic fibrosis: AA has effective anti-inflammatory and antioxidant activities, and regulates PI3K/AKT/mTOR signaling pathway to inhibit the activation of HSCs and ECM synthesis, thereby inhibiting hepatic fibrosis.[100] Oroxylin A, an extract of scutellaria baicalensis, inhibits PI3K/AKT/mTOR by scavenging ROS to activate autophagy, thereby inhibiting hepatic fibrosis.[101]