Yiqi Jiedu Huayu decoction can further inhibit mTOR pathway and promote autophagy by regulating PI3K/AKT and AMPK pathways, thereby improving podocyte injury, protecting renal function and reducing RF.[167] Metabolite Pearl Tiaozhi capsule can prevent renal injury, inflammation and fibrosis in mice with hyperuricemia-induced nephropathy by promoting uric acid excretion and inhibiting PI3K/AKT/NF-κB signaling pathway.[168] Jowiseungki decoction is a prescription commonly used in traditional medicine clinics to treat diabetic complications or DN. The gene discussed is AKT1; the disease is kidney disorder.