This recipe affects anti-reactive myocardial fibrosis in a dose-dependent mechanism mediated by activation of myocardial autophagy by the PI3K/AKT/mTOR pathway.[131–133] Zhenwu decoction improved cardiac function, myocardial pathology and myocardial fibrosis through TGFβ/SMAD-3 signaling pathway. Here, SMAD3 is linked to Myocardial fibrosis.