AKT1 and diabetic cardiomyopathy: (1) Metabolites inhibiting fibrosis by activating the PI3K/AKT signaling pathway: curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy by activating the Sirt1-Foxo1 and PI3K-AKT signaling pathways.[54] 8-Gingerol (8-Gin) is a series of phenolic substances extracted from ginger.