AKT1 and fibrosis: (4) Metabolites inhibiting fibrosis by inhibiting PI3K/AKT signaling pathway and affecting other biological processes: gambogic acid (GA), the main metabolite of Garcinia gambogic, inhibits hepatic fibrosis by inhibiting HSP90, inhibiting PI3K/AKT pathway, inducing autophagy and mitochondria-mediated apoptosis.[99] Asiatic acid (AA) is a triterpenoid metabolite isolated from Centella asiatica.