It has a cardioprotective effect on ISO-induced myocardial fibrosis.[55] Allicin pretreatment can prevent myocardial ischemia-reperfusion injury and activate the miR-19a-3p/PI3K/AKT pathway, thereby reducing myocardial fibrosis.[56] Astragalus membranaceus (Cal), the main active ingredient of Astragalus membranaceus, has been reported to have therapeutic effects on cardiac dysfunction after myocardial infarction. The gene discussed is AKT1; the disease is Myocardial fibrosis.