The flavonoid moiety, the main active metabolite of propolis, has a wide range of biological activities and can reduce myocardial fibrosis by promoting the PI3K/AKT pathway.[62] The combination of Aconite radix aconiti and Angelica sinensis can reduce myocardial fibrosis and inflammatory reaction, protect ischemic cardiomyocytes, and reduce myocardial injury. This evidence concerns the gene AKT1 and Myocardial fibrosis.