(2) Metabolites inhibiting fibrosis by inhibiting PI3K/AKT signaling pathway: Salidroside attenuated myocardial remodeling in DOCA salt-induced mice by inhibiting endothelin-1 and PI3K/AKT/NFκB signaling pathways.[64] Lucitol, a natural triterpenoid metabolite with anti-inflammatory and antiapoptotic activities, has a potential protective effect against cardiovascular disease and prevents cardiac hypertrophy through an anti-inflammatory mechanism, which is due to the inhibition of TLR4-PI3K-AKT-NF-κB signaling.[65]. This evidence concerns the gene AKT1 and cardiac hypertrophy.