VEGFA and sarcopenia: The generic transcription pathway plays a critical role in regulating genes associated with aging, muscle weakness, and bone loss.[31] Enhanced VEGF signal transduction has been shown to mitigate age-associated capillary degeneration, improve organ perfusion, and alleviate conditions such as hepatic steatosis, sarcopenia, and osteoporosis.[32] The regulation of gene expression, which is fundamental to the development and survival of all organisms, commences with the transcription process catalyzed by RNA polymerase.