The generic transcription pathway plays a critical role in regulating genes associated with aging, muscle weakness, and bone loss.[31] Enhanced VEGF signal transduction has been shown to mitigate age-associated capillary degeneration, improve organ perfusion, and alleviate conditions such as hepatic steatosis, sarcopenia, and osteoporosis.[32] The regulation of gene expression, which is fundamental to the development and survival of all organisms, commences with the transcription process catalyzed by RNA polymerase. This evidence concerns the gene VEGFA and osteoporosis.