PTPN11 and gastric cancer: Gastric cancer is thought to be an inflammation-induced tumor model, so inflammation undoubtedly increases the risk of gastric cancer.[24] In addition, some H pylori carry the Cagl gene, which promotes intracellular translocation of the caga protein target and further interaction with cytoplasmic SHP-2, SHP-2 is an oncogenic protein and increases the level of inflammation in stomach tissue.[25,26]H pylori can produce ammonia to neutralize stomach acid, which favors the growth of bacteria that break down nitrates.