ALDH2 and hepatocellular carcinoma: Additionally, multivariate Cox regression analysis demonstrated that patients with the ALDH2 rs671 genotype GA/AA had the highest HCC recurrence rate (hazard ratio [HR]: 3.48, 95% confidence interval [CI]: 1.08–12.4, P = .039), followed by those with multiple liver tumors (HR: 3.06, 95% CI: 1.11–10.9, P = .045) (Table 2).