To exemplify, levels of anti-cytomegalovirus (anti-CMV), produced when the body is infected by human CMV, are independently related to the increasing epithelial intestinal damage and translocation of microorganism,[8] also related to multiple dyspeptic outcomes.[9] Meanwhile, studies have shown that anti-CMV IgG levels increase the levels of inflammatory factors, such as C-X-C motif chemokine 13, IL-6, IL-8, and TNF-α.[8] Imbalance of factor response mechanisms is a key pathologic mechanism in GERD. This evidence concerns the gene TNF and gastroesophageal reflux disease.