The reverse MR analysis indicated a significant causal correlation between GERD and genetic susceptibility to 3 antibody-mediated immune responses, while no substantial relevance was detected between 43 other antibody-mediated immune responses, including H pylori IgG, H pylori CagA, H pylori GroEL, and H pylori VacA (Fig. 5). The gene discussed is S100A8; the disease is gastroesophageal reflux disease.