Forward MR outcomes indicated that the genetic susceptibility of 3 antibody-mediated immune responses associated and GERD risk have a positive causal relationship, while that of 43 other antibody-mediated immune responses including H pylori IgG, H pylori CagA, H pylori GroEL, and H pylori VacA showed no evidence of significant association with GERD risks (Fig. 2). This evidence concerns the gene S100A8 and gastroesophageal reflux disease.