Besides, C-X-C motif chemokine 1 (OR = 1.052, 95% CI: 1.004–1.103, P = .035), interleukin-1-alpha (OR = 1.083, 95% CI: 1.018–1.152, P = .012), and interleukin-4 (OR = 1.081, 95% CI: 1.018–1.147, P = .011) were positively related to GERD, and the tumor necrosis factor ligand superfamily member 12 (OR = 0.958, 95% CI: 0.917–1.000, P = .049) was negatively correlated Table S11, Supplemental Digital Content, https://links.lww.com/MD/P357). This evidence concerns the gene TNFSF12 and gastroesophageal reflux disease.