PROX1 and neoplasm: On the other hand, another study in oral squamous cell carcinoma (OSCC) showed that Local tumor progression, clinical stage, lymphovessel density (LVD), nodal metastasis, and a poorer prognosis were all substantially correlated with Prox1 expression showing that Prox1 activates the expression of vascular endothelial growth factor (VEGF)-C, which controls cell growth, proliferation, lymphangiogenesis and invasion [12, 29].