CBLN1 and posterior cortical atrophy: For high grade ISUP > 2 PCa, all 10 LASSO models identified a greater number of relevant variables, with four showing a positive association with the outcome (PSA, age, CVD, Cer-20) and eight showing a negative association (physical activity, SM-24, HexCer-24.1, GM3-18, LacCer-24, Cer-16, Gb3-24, DHCer-24).