MNX1 and acute myeloid leukemia: For example, in the AML-M4 cell line GDM-1, the oncogenic transcription factor Motor Neuron and Pancreas Homeobox 1 (MNX1) [3, 4] is aberrantly activated through enhancer hijacking due to a translocation t(6;7) which juxtaposes MNX1 on chromosome 7 (chr7) with enhancers from the MYB-AHI1 region on chr6 [3–5].