An in vitro study revealed that exosomes isolated from oxidative stress trophoblasts increase DNA damage-inducible transcript 4 (DDIT4) expression levels to trigger the inflammatory response to pyroptosis in endothelial cells through interactions with protein disulfide isomerase family a member 4 (PDIA4), which exacerbates preeclampsia [204]. This evidence concerns the gene DDIT4 and preeclampsia.