AD-associated DAM/MgnD exhibited a noteworthy gene signature with high expression levels, including Itgax (integrin subunit alpha x), Clec7a (C-type lectin domain containing 7A), Trem2 (triggering receptor expressed on myeloid cells 2), Apoe (apolipoprotein E), Lpl (lipoprotein lipase) and Cst7 (cystatin 7). Here, APOE is linked to Alzheimer disease.