IL1RL1 and myeloid leukemia: Serial transplantations further underscored the functional requirement of Il1rl1 in initiating myeloid leukemia and revealing that Il1rl1 deficiency in LSCs significantly reduced the ability of leukemogenesis initiation, as evidenced by lower leukemic cells and LSCs infiltrates in the BM compared to wild-type leukemic cells and LSCs.