For a direct clinical translation, we also built an anti-human IL1RL1 system to study human T cells against human AML, using the same IgG[L]-scFv platform built from humanized anti-IL1RL1 blocking antibody55, humanized anti-CD3 OKT3 (BC282) and its humanized control (BC283). Here, IL1RL1 is linked to acute myeloid leukemia.