Using the cbfb-MYH knock-in mice, Wang et al. identified that Il1rl1 is dynamically expressed in LSCs, and conditional knockout of Il1rl1 in Cbfb-MYH11+ leukemia under an inducible hematopoietic-specific Mx1 Cre model confirmed the role of Il1rl1 in initiating leukemogenesis in the leukemia model7. Here, MYH11 is linked to leukemia.