We utilized transcriptomic datasets of molecularly defined AML subgroups from the FHCC AML dataset including IDH1mut, IDH2mut, NPM1mut, CEBPAmut, FLT3ITD, FLT3TKD, NRASmut, EVI1POS and found that IL1RL1 was elevated in all these groups compared to normal HD HSCs21 (Fig. 1E). This evidence concerns the gene IL1RL1 and acute myeloid leukemia.