However, in the BM niche of IL-33cit/cit KO LSCs recipient mice, WT-1-tetramer+CD8+ T cells increased significantly more compared to IL-33WT counterparts (Fig. 4D) suggesting more antigen specific CD8+ T cells are available to kill the tumor in recipients for which the LSCs IL-33/Il1rl1 autocrine loop in LSCs has been deactivated. The gene discussed is IL1RL1; the disease is neoplasm.