ACSL4 and pancreatic ductal adenocarcinoma: Similarly, in pancreatic ductal adenocarcinoma (PDAC) and NALM-6 leukemia cells, membrane lipid remodeling involving polyunsaturated fatty acid–cholesterol esters (PUFA-CEs)—generated via the acyl-CoA synthetase long-chain family member 4 (ACSL4)–sterol o-acyltransferase 1 (SOAT1) pathway and regulated by solute carrier family 47 member 1 (SLC47A1)—drives ferroptotic sensitivity [59].