ATG5 and neoplasm: However, in cells overexpressing DHX9, where BECN1 expression was significantly decreased, upregulation of ATG5 failed to reverse the autophagy-inhibition and tumor-promoting effects induced by DHX9 overexpression (Figure S4K–M), which contrasted with the marked reversal effects observed upon BECN1 upregulation in the same cellular context (Figure S4N–P).