However, in cells overexpressing DHX9, where BECN1 expression was significantly decreased, upregulation of ATG5 failed to reverse the autophagy-inhibition and tumor-promoting effects induced by DHX9 overexpression (Figure S4K–M), which contrasted with the marked reversal effects observed upon BECN1 upregulation in the same cellular context (Figure S4N–P). This evidence concerns the gene BECN1 and neoplasm.