White blood cell count (WBC, HR = 1.141, 95%CI: 1.026 – 1.268, p = 0.015), hemoglobin (HR = 0.969, 95%CI: 0.946 – 0.993,p = 0.010), BUN (HR = 1.077, 95%CI: 1.045 – 1.111, p < 0.001), Scr (HR = 1.002, 95%CI: 1.001 – 1.003, p < 0.001), uric acid (HR = 1.005, 95%CI:1.002 – 1.008, p = 0.003), C4 (HR = 1.837, 95%CI:1.096 – 3.081, p = 0.021), digestive system (HR = 3.335, 95%CI: 1.183 – 9.398, p = 0.023) was associated with ESKD in ANCA-associated vasculitis patients. The gene discussed is C4A; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.