While pathogenic variants in FBN1 are also associated with an increased risk for dilated cardiomyopathy in both patients and mice, FBN1 is expressed in many cell types, including SMCs, cardiomyocytes, and cardiac fibroblasts [30], making it challenging to determine which cell type is primarily responsible for cardiomyopathy. The gene discussed is FBN1; the disease is dilated cardiomyopathy.