COL12A1 and obesity due to melanocortin 4 receptor deficiency: In contrast, the adipogenesis genes COL12A1, FBN1 and RBP4, as well as the genes CASP6 and DPT that involved in inflammation or immune response, were downregulated in obese pigs but upregulated in obese human (Fig. 3B, top panel; S4 Table), consistent with previous reports showing their upregulation in obesity (S4 Table).