For example, ALDOB, EXTL1, and OSBPL10 (involved in metabolism), as well as FGF21 (a myokine, which protects from diet-induced obesity and insulin resistance [65,66]) were upregulated in the skeletal muscle of obese pigs (Fig. 3B; S4 Table, the biological function annotation of high divergent genes), whereas these genes have been reported to be downregulated in obese humans or mice [67–71]. The gene discussed is EXTL1; the disease is obesity due to melanocortin 4 receptor deficiency.