While small sample sizes constitute a clear limitation in this and many prior investigations of aphasia recovery beginning in the acute phase, another major issue in studies examining BDNF polymorphisms, as also emphasized by Mayes et al. [46], is the uneven distribution across populations and underrepresentation, at least in some samples, of atypical BDNF genotypes, particularly Met/Met individuals. This evidence concerns the gene BDNF and Aphasia.