ANXA2 and neoplasm: ANXA2 is considered to be a cellular receptor for plasminogen (PLG), often expressed on the surface of endothelial cells, macrophages, and tumor cells, which activates a cascade of pro-angiogenic factors by promoting the conversion of PLG to plasmin, thereby promoting angiogenesis and tumor progression (Semov et al., 2005; Sharma, 2019).