Therefore, we analyzed expression patterns of circAGFG1, miR-195-5p, and PD-L1 in sepsis-induced ALI patients to elucidate the mechanism underlying regulation of the circAGFG1/miR-195-5p/PD-L1 axis in airway epithelial cells and a sepsis-induced ALI murine model. The gene discussed is CD274; the disease is Sepsis.