CD274 and Sepsis: With or without over-expression of circAGFG1 treatment, the PD-L1 levels in wild-type lung epithelial cells treated with CLP had comparable levels of PD-L1 expression with those in PD-L1 KO mice (Fig. 8B and Supplemental Fig. 10), indicating that sepsis may suppress PD-L1 expression in lung epithelial cells through miR-195-5p, a phenomenon that may be counteracted by treatment with exogenous circAGFG1.