KCNH2 and cardiac arrhythmia: As a proof of concept, we applied this approach to the human voltage-gated potassium channel KV11.1, encoded by the KCNH2 or human Ether-à-go-go-Related Gene (hERG) gene, a well-known drug anti-target in pharmacology and cardiology due to its role in drug-induced arrhythmias.