The RANKL/RANK system in the CNS plays a vital role in regulating body temperature,[181] energy metabolism,[182] cerebral ischemia,[177] and autoimmune encephalitis.[179] RANKL activation is involved in the brain regions responsible for thermoregulation, inducing fever via the cyclooxygenase‐2 (COX‐2)/ prostaglandin E2 (PGE2)/ prostaglandin E receptor 3 (EP3R) pathway. This evidence concerns the gene TNFSF11 and autoimmune encephalitis.