Protective lncRNAs can alleviate sepsis-induced renal injury through their upregulation; for instance, overexpression of CASC9 reduces cellular inflammation and apoptosis both in vivo and in vitro, enhances cellular antioxidant capacity, and diminishes sepsis-induced renal injury (Wang et al., 2020c; Fan et al., 2021). The gene discussed is CASC9; the disease is Sepsis.