Incorporation of Arc protein shells during cellular sEV synthesis efficiently encapsulates mRNA and enables targeted gene delivery to neurons.[57] In GBM cells, some surface proteins are up‐regulated in GBM cells compared to normal brain tissues (such as intercellular cell adhesion molecule‐1 (ICAM‐1),[58] TfR,[34] and LRP1[59]). This evidence concerns the gene ARC and glioblastoma.