Epigenetic regulation is the chemical modification of genes or gene products, including methylation of DNA or RNA and regulatory effects of non‐coding RNAs (miRNAs, lncRNAs, circRNAs).[4] For example, high expression of methylated reader YTHDF2 recognizes METTL3‐mediated m6A modification, which activates the NF‐κB signaling pathway and promotes the malignant progression of GBM.[5] Currently, in response to mutations and abnormal epigenetic regulation, researchers have designed a range of gene drugs to perform interventions. The gene discussed is YTHDF2; the disease is glioblastoma.