While most of genes modulated CVD risk through gene expression changes in various tissues, some exerted effects specifically in just one tissue, for example, FGF5 modified disease risks for angina, myocardial infarction and atrial fibrillation all in the kidney cortex, and PROCR gene expression in the heart atrial appendage tissue may change risk of myocardial infarction. This evidence concerns the gene FGF5 and myocardial infarction.