Studies have suggested that BNP may play different roles in heart failure with preserved and reduced ejection fraction (HFpEF and HFrEF, respectively),[59] and BNP or NT‐proBNP were less effective biomarkers for HFpEF due to their average lower values in HFpEF than in HFrEF, which can drop into a normal range in some patients.[60] Our finding is consistent with these studies that BNP‐related biomarkers were mainly indicative for heart diseases with reduced left ventricle ejection fraction. The gene discussed is NPPB; the disease is heart disorder.