ALDH3A1 and cancer: ALDH3A1 expression is mutated in an increasing number of cancers, particularly OSCC, but its loss or decrease may reflect altered differentiation and it could also be a marker of tumorigenesis.30, 31, 32, 33, 34 Recently, ALDH3A1 was identified as a promising prognostic biomarker in different malignancies, and it was correlated with diverse clinical outcomes in various cancers.35