FOXO1 and Insulin resistance: In addition, some studies have found that GLP-2 regulates hepatic glucose metabolism in mice through the activation of the GLP-2R-PI3K-Akt-FoxO1 signaling pathway, and mice that lack GLP-2 receptors show glucose intolerance and hepatic insulin resistance (IR), which means that GLP-2 contributes greatly to the control of glucose homeostasis and insulin sensitivity 40.