Similarly, in renal cancer cells, the depletion of PIK3R1 promotes AKT phosphorylation, proliferation, migration, epithelial-to-mesenchymal transition, and the emergence of stem cell-like properties via the AKT/GSK3β/CTNNB1 pathway, potentially contributing to the progression and metastasis of renal cell carcinoma 19. The gene discussed is AKT1; the disease is hereditary clear cell renal cell carcinoma.