Animal experiments further confirmed that ACTL6A silencing significantly reduced lung metastasis burden of orthotopic xenografts, accompanied by decreased GSH/GSSG ratios and accumulated lipid peroxidation markers (e.g., MDA) in tumor tissues.77 Notably, targeted intervention of the GSH synthesis pathway combined with standard chemotherapy drugs (e.g., BSO) synergistically induced GC cell death, providing a novel strategy to overcome chemoresistance in gastric cancer. This evidence concerns the gene ACTL6A and neoplasm.