ACTL6A and cancer: Gastric cancer (GC) is a common and deadly malignancy, remaining a leading cause of cancer-related mortality.73,74 Despite recent advances in diagnosis and treatment, its aggressive nature, high metastatic potential, and lack of early symptoms often lead to late-stage diagnoses and poor prognosis.75 The development of GC involves multiple signaling pathways and molecular mechanisms.76 Recently, researchers have focused on identifying molecular markers associated with GC invasion and metastasis, with ACTL6A receiving significant attention.