Multi-omics integrated analysis identified ACTL6A as a core member of invasion-associated gene signatures, with its high expression strongly correlated with shortened overall survival in ovarian cancer patients.95 Gene set enrichment analysis (GSEA) further revealed that ACTL6A coordinately promotes tumor cell proliferation and matrix detachment through dual regulation: positive modulation of the "cell cycle" pathway and negative regulation of the "focal adhesion" pathway. The gene discussed is ACTL6A; the disease is ovarian cancer.