Basic research has revealed that it promotes epithelial-mesenchymal transition (EMT) via the SOX2/Notch1 signaling axis, increasing HCC cell invasion capacity.42 Notably, Wang et al.10,43,44 first identified the regulatory role of E3 ubiquitin ligase FBXW7 on ACTL6A: in HCC tissues, FBXW7 expression negatively correlated with ACTL6A. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.