Squamous cell carcinoma (SCC), a highly aggressive tumor originating from stratified squamous epithelium, is closely associated with epigenetic regulatory abnormalities.50-52 Recent studies indicate that ACTL6A, a core subunit of the SWI/SNF chromatin remodeling complex, exerts oncogenic effects in SCC through integrating multiple signaling pathways, with its molecular mechanisms demonstrating significant complexity.48,53. Here, ACTL6A is linked to neoplasm.