AKT1 and colorectal carcinoma: Colorectal cancer (CRC) is a leading global malignancy with rising incidence and mortality rates.78,79 Its development is driven by the dysregulation of key molecular pathways, including Wnt/β-catenin,80 PI3K/Akt,81 and MAPK.82 Recent studies have identified abnormal expression of specific molecular markers in CRC that are closely linked to these aggressive behaviors.83