Notably, genetic polymorphisms in DEP domain-containing mTOR-interacting protein (DEPTOR), an endogenous mTOR inhibitor, and other mTOR pathway components, like Regulatory Associated Protein of mTOR Complex 1 (RPTOR), have been linked to altered IPF risk, emphasizing the genetic modulation of mTOR-driven fibrosis 57. Here, DEPTOR is linked to idiopathic pulmonary fibrosis.