Because nearly one-third of OCSCC patients in our cohort had rs4702373 allele mutation and the mutant allele might be associated with higher NSUN2 expression, a total of 515 HNSCC patients from the TCGA database were divided into the two groups of high- (33.4%, 172/515) and low- (66.6%, 343/515) NSUN2 expression. Here, NSUN2 is linked to head and neck squamous cell carcinoma.