Cyclin D1, but not cyclin E, was decreased in isoindigo 5′-Br treated HL-60 cells 31, whereas both cyclins D1 and E were consistently inhibited in esophageal cancer cells 28, MCF-7 and T-47D breast cancer cells treated with niclosamide (Fig. 2C). Here, CCNE1 is linked to esophageal cancer.