KDM6A and pachyonychia congenita: A pancreatic cancer (PC) study using a pancreatic organoid model combined with multi-omics analysis found that GATA6 deficiency and Wnt deficiency synergizing with genetic or hypoxia-mediated KDM6A inactivation to promote squamous cell reprogramming, thereby enhancing the environmental adaptation of squamous cells, and then induced the development of pancreatic squamous cell carcinoma51.