For example, in oral squamous cell carcinoma (OSCC), circ_CDR1as can act as a sponge for miR-7, leading to the attenuation of the miR-7 targets RAF-1 and PIK3CD, which promotes metastatic progression of tumors by regulating the MAPK/AKT signaling pathway34. The gene discussed is PIK3CD; the disease is oral cavity squamous cell carcinoma.