A pancreatic cancer (PC) study using a pancreatic organoid model combined with multi-omics analysis found that GATA6 deficiency and Wnt deficiency synergizing with genetic or hypoxia-mediated KDM6A inactivation to promote squamous cell reprogramming, thereby enhancing the environmental adaptation of squamous cells, and then induced the development of pancreatic squamous cell carcinoma51. The gene discussed is GATA6; the disease is pachyonychia congenita.