The loss of GATA6 expression in pancreatic squamous cell carcinoma compared with classical pancreatic ductal carcinoma suggested that the restoration of GATA6 may induce the transformation of pancreatic squamous cell carcinoma to classical pancreatic ductal carcinoma, thereby improving the chemosensitivity of the tumor treatment drug folfirinox52. The gene discussed is GATA6; the disease is pancreatic ductal adenocarcinoma.