AKT1 and oral cavity squamous cell carcinoma: For example, in oral squamous cell carcinoma (OSCC), circ_CDR1as can act as a sponge for miR-7, leading to the attenuation of the miR-7 targets RAF-1 and PIK3CD, which promotes metastatic progression of tumors by regulating the MAPK/AKT signaling pathway34.