In addition, IVW analysis also found that FSC-A on HLA DR+ Natural Killer (OR = 0.78, 95%CI = 0.67~0.92, p = 0.003), CCR2 on CD14-CD16+ monocyte (OR = 0.83, 95%CI = 0.69~1.00, p = 0.046) and CD14 on Monocytic MDSCs (OR = 0.72, 95%CI = 0.56~0.93, p = 0.012) were negatively correlated with the risk of glioma, and Granulocyte Absolute Count (OR = 1.50, 95%CI = 1.12~2.02, p = 0.007), CD16+ monocyte %monocyte (OR = 1.41, 95%CI = 1.03~1.93, p = 0.032) and CD45 on CD33+HLA DR+CD14dim (OR = 1.29, 95%CI = 1.07~1.54, p = 0.007) were positively correlated with the risk of glioma. This evidence concerns the gene CD33 and glioma.