TLR4 and gangrene: RESATORVID, SECUKINUMAB, SILTUXIMAB, SPIRAPRIL, FOSINOPRIL, CLAZAKIZUMAB, CILAZAPRIL, IXEKIZUMAB, MOEXIPRIL, SUCRALFATE) corresponding to 6 essential genes (IL17A- interleukin 17 alpha, FGF2- fibroblast growth factor 2, ACE- angiotensin-converting enzyme, IGF1- insulin like growth factor 1 and TLR4- Toll like receptor 4, IL6-interleukin 6) were discovered to influence gangrene (Figure 4 and Table 1).