Critically, Porphyromonas gingivalis infection - a microbial driver shared by both oesophageal squamous cell carcinoma (ESCC) and OSCC 94 - promotes IFNGR1 palmitoylation, accelerating its lysosomal degradation and malignant progression in ESCC 95. Here, IFNGR1 is linked to esophageal squamous cell carcinoma.