As illustrated in Figure 1F, MFAP1, MFAP2 and MFAP3 were up-regulated in both EAC and ESCC, while MFAP4 and MFAP5 were down-regulated in cancer tissues, indicating that MFAP2 might play crucial role in ESCC. The gene discussed is MFAP2; the disease is esophageal squamous cell carcinoma.