Previous research has revealed complex β-catenin-SOX2 dynamics: in MCF7 breast cancer cells, β-catenin binds SOX2 to suppress its transcriptional activity, with β-catenin knockdown increasing SOX2 function 30, while in colorectal cancer, disrupting β-catenin signaling inhibits SOX2-driven chemoresistance 31. This evidence concerns the gene SOX2 and colorectal cancer.