Meanwhile, it has also been found that EMT-Exos-derived exosomal miR-106b can inhibit the expression of PDCD4 in macrophages, induce M2 macrophage polarization by activating PI3Kg/AKT/mTOR pathway, and promote the malignant progression of CRC cells 38. The gene discussed is AKT1; the disease is colorectal carcinoma.