For instance, the gene located at cg11909912 predicted that a one-fold increase in microtubule-associated protein tau (MAPT) methylation was associated with a reduced risk of BC (odds ratio [OR]: 0.81, 95% confidence interval [CI]: 0.74-0.89), whereas the gene located at cg11117266 predicted that a one-fold increase in MAPT methylation was associated with an increased risk of BC (OR: 1.20, 95% CI: 1.11-1.29). Here, MAPT is linked to breast cancer.