Abnormally high HOXB7 expression in gastric cancer is associated with patient clinical characteristics, enhanced the ability of gastric cancer cells to proliferate, migrate, and invade, while inhibiting apoptosis, by activating the PI3KR3/AKT signaling pathway or up-regulating p-AKT and down-regulating PTEN 46. The gene discussed is PTEN; the disease is gastric cancer.