HOXB-AS4 and head and neck squamous cell carcinoma: To further explore the possible mechanisms by which HOXB-AS4 contributes to the malignant phenotype of HNSCC, we performed GO (S3A) and KEGG (S3B) enrichment analyses on both HOXB-AS4 high- and low-expressing subgroups and found that significant enrichment was observed in the cellular components assembly involved in morphogenesis, as well as regulation of actin cytoskeleton and focal adhesion.