CASP8 and neoplasm: The results revealed an increase in KMT2D and CASP8 mutations, which are related to the tumor immune microenvironment, as well as an amplification of chromosome 9p24.1, and deletions of chromosomes 5q12.1, 5q15, and 5q35.3 in the HOXB-AS4 high-expression group (Figure 7D).