For example, lncRNA ELDR is closely located downstream of epidermal growth factor (EGF), which is highly expressed in various cancers such as HNSCC and ovarian cancer, and activates the downstream molecule STAT3 by stabilizing EGF, thus ELDR plays a carcinogenic role and serves as a prognostic marker for various cancers 41-43. This evidence concerns the gene STAT3 and cancer.