In this study, by integrating CRISPR-CAS9 functional genomics (DEPMAP database) and TCGA multi-omics data, seven key genes (CDK7, CLTC, COPB2, CRNKL1, GSPT1, NSF and PSMD12) that are closely related to the proliferation and prognosis of breast cancer were systematically identified. Here, COPB2 is linked to breast carcinoma.