Although APCI1307K is unexpectedly common in our cohort of Arab patients with cancer, in addition to CRC, the rates of this APC variant are also unexpectedly high among patients with breast cancer, which led to our recommendation of adding the APC gene to at least the multi-gene panel used in the routine GGT of patients with colorectal and breast cancers. The gene discussed is APC; the disease is breast carcinoma.