KLRK1 and neoplasm: Panobinostat (10–20 nM) activates the Wnt/β-catenin signaling pathway by increasing the level of histone H3K27 acetylation in the β-catenin promoter region, thereby significantly upregulating the expression of NKG2D ligands MICA and MICB on the surface of soft tissue sarcoma cells, and subsequently enhancing the killing efficiency of NK92 cells and pNK cells against tumor cells (44).