For Ki-67, the CF model achieved an AUC of 0.746 (95% CI: 0.640-0.853), higher than those of the whole-tumor model (AUC = 0.680, 95% CI: 0.562-0.798) and habitats model (AUC = 0.685, 95% CI: 0.567-0.803). This evidence concerns the gene MKI67 and neoplasm.