CX3CL1 and neoplasm: This binding attracts macrophages toward ACs, facilitating the “find me” process.[72] Importantly, CX3CL1 secretion also triggers the expression of MFG‐E8 and reinforces integrin binding to ACs.[73] Moreover, studies suggest that CX3CL1‐CX3CR1 signaling reduces inflammatory cytokine expression and boosts antioxidant factor production, expediting the establishment of an anti‐inflammatory TME and fostering tumor progression.[74, 75, 76] Consequently, inhibiting this pathway also suppresses efferocytosis.